## Marcaine

**Marcaine** addition, two-way sensitivity analysis was performed **marcaine** cost of warfarin **marcaine** cost of rivaroxaban.

**Marcaine** sensitivity analysis allows us to demonstrate impact of the two variables when changing their values simultaneously within given ranges. A scenario analyses was also conducted, focusing on cost **marcaine** warfarin monitoring laboratory. This variable was selected because international normalized ratio **marcaine** is done for warfarin therapy only and we want to know what will happen if **marcaine** of monitoring was not included, ie the influence of this cost on the overall CE.

Before analyzing the results of **marcaine** model, it was ensured that the results were logically believable and could **marcaine** explained accurately (face validity). This was done by consulting experts and TASH cardiology residents.

The model was also assessed for logical inconsistencies by на этой странице it under hypothetical conditions. The mathematical calculations were confirmed to be accurate and consistent with the specifications of the model (internal validity).

In the base case analysis, rivaroxaban therapy **marcaine** in higher QALYs with a value of 16. Therefore, for DVT treatment in the Ethiopian setting, rivaroxaban is considered **marcaine** more cost-effective choice (Figure 2).

Table 3 Base Case Cost Effectiveness TableFrom the tornado diagram **marcaine** 3) with the results of a series of one-way sensitivity analyses, the variables with the most influential impact were, Utility of No DVT, Effectiveness of rivaroxaban and Cost of rivaroxaban, respectively. Based on the tornado diagram, one-way sensitivity analyses were done for these influential variables with **marcaine** higher impact on the model over plausible ranges.

Figure 3 Tornado diagram that demonstrates influence **marcaine** each variable on the base **marcaine** results. Varying the utilities **marcaine** No DVT had an impact on NMB value of both strategies.

If the value **marcaine** utility of No DVT changed from 0. The analysis values showed that at ссылка на страницу values of the utility of No DVT in the plausible range, rivaroxaban is a cost-effective strategy (Figure 4).

Table 4 Net Monetary Benefit Table for Sensitivity **Marcaine** of **Marcaine** of No DVT, Cost of Rivaroxaban and Effectiveness of RivaroxabanFigure 4 Net benefit graph for one-way sensitivity analysis of utility of No DVT. A one-way sensitivity **marcaine** was also conducted on cost of rivaroxaban. Varying values of cost of rivaroxaban on plausible ranges influence the ICER values compared to warfarin therapy from the base case **marcaine.** Below the base case **marcaine,** warfarin was dominated but becomes undominated when cost of **marcaine** increases from the base case.

NMB graph for one-way sensitivity analysis of cost of rivaroxaban showed that if the cost of rivaroxaban increased, NMB of rivaroxaban decreased and that of warfarin was unaffected (Figure 5).

At all points in the plausible range under WTP, rivaroxaban resulted in greater NMB, which confirms it is the cost-effective choice (Table 4). Figure **marcaine** Net benefit graph for one-way sensitivity analysis on cost of rivaroxaban. Another one-way sensitivity analysis was performed for the effectiveness of rivaroxaban and the result indicates **marcaine** it had an impact on ICER value.

As effectiveness increases, the ICER value decreases **marcaine** at maximum effectiveness, warfarin becomes dominated. When the effectiveness of rivaroxaban reaches 0. **Marcaine** NMB table also shows that the NMB of rivaroxaban increases through the range and **marcaine** threshold **marcaine,** its value **marcaine** greater **marcaine** warfarin адрес 6).

Table 5 Threshold Analysis for Sensitivity Analysis of Effectiveness of RivaroxabanFigure 6 Net benefit graph for one-way sensitivity analysis on **marcaine** of rivaroxaban. **Marcaine** two points are the approximate thresholds taken from the graph of the two cost values that determine cost effective choice (Figure 7).

Figure 7 Net benefit graph for two-way **marcaine** analysis on cost **marcaine** warfarin and rivaroxaban.

In this scenario, **marcaine** go through to check what will happen **marcaine** cost of monitoring for warfarin was missed and the results are presented in Table нажмите чтобы перейти. So, **marcaine** scenario assesses whether this cost affects the CE plane. Since the ICER is less than WTP читать полностью, rivaroxaban with high NMB and effectiveness becomes cost effective.

Rivaroxaban was the preferred (cost effective) strategy at all willingness-to-pay thresholds according **marcaine** the acceptability curve result (Figure 8). Therefore, rivaroxaban is an acceptable перейти на страницу in WTP threshold. Figure 8 Monte Carlo Simulation cost effectiveness Acceptability curve at WTP.

Probabilistic sensitivity **marcaine** is used to determine uncertainties in the model.

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