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Although Tseng et al. This may be attributed to the different status of seizure control. Further large studies are required to explore the correlation between free VPA serum по этому сообщению and hyperammonemia.

This study bristol myers squibb company common stock some limitations. Third, multiple concentrations for each patient were used for analysis, смотрите подробнее may have affected the robustness of our results.

We used the last value for each patient for sensitivity analysis, which revealed that free VPA serum concentration and baseline platelet count were still significant predictors for the occurrence of thrombocytopenia, further strengthening our result. Lastly, we did not evaluate the association between free VPA serum concentration and efficacy.

Free VPA concentrations lower than the safety range may be associated with reduced seizure control. Further research should evaluate the association between free VPA serum concentration and efficacy to determine the optimal therapeutic range. Free VPA serum concentration seems to be a risk factor for thrombocytopenia but not for hyperammonemia.

The value of 14. Ammonia should be closely monitored even if free VPA serum concentration is within the safety range. Is the Subject Area "Thrombocytopenia" applicable to this article. Yes NoIs the Subject Area "Albumins" applicable to this article.

Yes NoIs the Subject Area "Platelets" applicable to this article. Yes NoIs the Subject Area "Intensive care units" bristol myers squibb company common stock to this article.

Yes NoIs the Subject Area "Ammonia" applicable to this article. Yes NoIs the Subject Area "Bilirubin" applicable to this article. Yes NoIs the Subject Area "Adverse reactions" applicable to this article. Objective To determine the optimal safety range of free VPA concentration in adult patients. Materials and ссылка на продолжение This prospective cohort study enrolled adult patients undergoing VPA therapy with TDM. Results A total of 98 free serum concentrations from 51 patients were included for final analysis.

Conclusions A free VPA serum concentration of 14. IntroductionValproic acid (VPA) has been used extensively as migraine prophylaxis and in the treatment of seizure, bipolar disorder, and other psychiatric or neurological conditions. Materials and methodsThis prospective cohort study was conducted from April 1, 2018 to March 31, 2019 at National Taiwan University Hospital (NTUH), which is a 2600-bed tertiary referral center in northern Taiwan. ResultsA total of 98 serum concentration data points from 51 participants were included for final analysis.

Demographic and clinical characteristics for TDM episodes. Scatterplot of adverse effect and free valproic acid serum concentration. Receiver operating characteristic curve of free valproic acid concentration bristol myers squibb company common stock the cutoff value of 14. Association of adverse effects and free or total valproic acid bristol myers squibb company common stock. Factors associated with the взято отсюда of thrombocytopenia.

ConclusionsFree VPA serum concentration seems to be a risk factor for thrombocytopenia but not for hyperammonemia. Data set for analysis.

Patsalos PN, Berry DJ, Bourgeois BF, Cloyd JC, Glauser TA, Johannessen SI, et al. Antiepileptic drugs-best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. Sandson NB, Marcucci C, Bourke DL, Smith-Lamacchia R.

An interaction between aspirin and valproate: the relevance of plasma protein displacement drug-drug interactions. Dore M, San Juan AE, Frenette AJ, Williamson D. Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients bristol myers squibb company common stock Hypoalbuminemia. Gugler R, von Unruh GE. Clinical pharmacokinetics of продолжить чтение acid.

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Comments:

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